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|Product Name:||β-Estradiol||CAS NO:||50-28-2|
|Appearance:||White Crystalline Powder||Assay:||98%|
Pharmaceutical material Steroids β- Estradiol Female Sex Hormones CAS 50-28-2 , EINECS 200-023-8
This product is white or milky white odorless crystalline powder; In dioxane, dissolved in acetone, slightly soluble in ethanol, insoluble in water.
Estradiol is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.
The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.
As a sex hormone, it also triggers many of the developments of the reproductive system that begin in puberty. It is present throughout the reproductive years, and declines during and after menopause. This decline is precisely what causes many of the symptoms of menopause, such as hot flashes and night sweats, vaginal dryness, and the loss of bone mass that may lead to osteoporosis.
Estradiol for functional uterine bleeding, primary amenorrhea, menopausal syndrome, prostate cancer. Can promote and regulate the female sexual organs and sexual characteristics of the normal development. Can promote the development of mammary duct proliferation, but in a larger dose, can inhibit the release of anterior pituitary prolactin, while reducing milk secretion. Can also be used to return milk. But may have nausea, vomiting and endometrial hyperplasia and bleeding. Liver and kidney dysfunction with caution. Avoid for the breast, vulva and vaginal mucosa.
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|CAS register number||50-28-2|
|Description||White crystalline powder||White crystalline powder|
|Loss On Drying||0.5%max||0.30%|
|Specific Rotation||+76~ +83||+78.7|
|Related Substances||total impurities ≤1.0%||conform|
|Related Substances||any individual impurity ≤0.5%||conform|
|Conclusion||The specification conform with enterprise standard|